Current Issue : October-December Volume : 2014 Issue Number : 4 Articles : 5 Articles
The objective of the study was to evaluate the anti-hyperglycemic activity of different solvent extracts of Momordica dioica seeds in both normal and diabetic rats. Diabetes was induced by Streptozotocin (30-50 mg/kg) intraperitoneally, rats which showed glucose >250 mg/100 ml of blood were selected for the study. Metformin was given as a standard drug at a dose of 50 mg/kg orally. OGTT was performed in normal and diabetic rats. The Chloroform and Ethylacetate extracts of M.dioica seeds were prepared and administered orally. The blood glucose levels were estimated by glucose-oxidase method. The hypoglycemic activity of M.dioica seed extracts was observed in normal rats with significant decrease in blood glucose levels, (p<0.0001) at 1 hr, 2 hr and 4 hr. Anti-hyperglycemic activity of the test drug was observed with a significant reduction in blood glucose levels (p<0.0001) at 1 hr, 2hr and 4 hrs. The results suggested that the two different extracts of Momordica dioica seeds may have potent anti-diabetic activity, justifying the use of drug for the treatment of Diabetes mellitus....
Curcuma caesia (Family: Zingiberaceae) is being used in traditional medicine for the treatment of severe bronchitis and asthma. So the aim of study was to evaluate antiasthmatic activity of various extracts of curcuma caesia rhizomes to validate its traditional use. In the present study petroleum ether, ethanol and water extract of Curcuma caesia rhizomes at the doses of 25 -100 mg/kg i. p. was evaluated for antiasthmatic activity using milk induced eosinophilia in mice. The results of present investigation showed that the ethanol extract of Curcuma caesia rhizomes at (25 -100 mg/kg, i.p.) significantly decreases milk induced eosinophilia in mice in a dose dependent manner when compared to petroleum ether, water extract and control group. It can be concluded that the ethanol extract of Curcuma caesia (CCEE) may be used in management of asthma....
Curcuma caesia (Family: Zingiberaceae) is being used in traditional medicine for the treatment of severe bronchitis and asthma. So the aim of study was to evaluate antiasthmatic activity of various extracts of curcuma caesia rhizomes to validate its traditional use. In the present study petroleum ether, ethanol and water extract of Curcuma caesia rhizomes at the doses of 25-100 mg/kg i. p. was evaluated for antiasthmatic activity using milk induced leucocytosis in mice. The results of present investigation showed that the ethanol extract of Curcuma caesia rhizomes at (25-100 mg/kg, i.p.) significantly decreases milk induced leucocytosis in mice in a dose dependent manner when compared to petroleum ether, water extract and control group. It can be concluded that the ethanol extract of Curcuma caesia (CCEE) may be used in management of asthma....
Present study was undertaken to evaluate analgesic and anti inflammatory activities of Raphanus sativus leaves in animal model. Plant material was collected, shade dried and subjected to maceration by using ethanol and water mixture as solvent. Extract was calculated for percentage yield and subjected for preliminary phytochemical screening using standard procedures. Analgesic activity was evaluated by hot plate and tail immersion method where as anti inflammatory activity was done by carrageenan method. Investigation on analgesic and anti inflammatory activities of Raphanus sativus leaves was performed at two dose levels that are 250 and 500 mg/kg. The results from above parameters indicates that the extract posses significant (p<0.05) analgesic and anti inflammatory activities. Raphanus sativus leaves extract showed significant results (p<0.05) at the higher dose group that is HARS 500 mg/kg body weight. So from the above results, it can be concluded that the analgesic and anti inflammatory activities of the plant are dose dependent. Therefore, it is worthwhile to carryout in detailed and thorough research on the mechanism by which the plant extract exerting this analgesic and anti inflammatory activities....
In the traditional medicinal practices, several formulations containing Terminalia chebula are used for cognitive improvement. Alzheimer’s disease (AD) is the most common type of dementia disorder of elderly affecting millions of people. The pathophysiology of the disease is complex and involves multiple pathways of neuronal damage. In the present study nootropic acitivity of ethanolic extract of Terminalia chebula was studied in albino rats. In order to evaluate the beneficial effect of Terminalia chebula on learning and memory, an experimental study was conducted in albino rats of either sex. In this study we used a morris water maze apparatus to evaluate the active avoidance learning and memory in mice. Different doses of ethanolic extract of Terminalia chebula (50, 75 and 100 mg/ml) were administered to animals in the test groups. The learning ability and memory recalls were assessed and compared statistically with those of control animals. Our data showed that there is a significant increase in cognitive function was observed in rats receiving various doses 50, 75 and 100 mg/ml. The degree of percent reduction was more in rats receiving 100 mg/ml of extract. Our findings indicate that acute administrations of ethanolic extracts of Terminalia chebula enhance the learning and memory recall ability in rats....
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